Coronary artery size and dilating capacity in ultradistance runners.
نویسندگان
چکیده
BACKGROUND Increases in coronary artery size and dilating capacity have been observed in some animals after endurance training, and at autopsy, active men appear to have enlarged epicardial coronary arteries. This cross-sectional study was designed to test the hypothesis that highly trained endurance runners have larger epicardial coronary arteries and greater dilating capacity than inactive men. METHODS AND RESULTS The subjects, ages 39-66 years, included 11 male volunteers who had participated in ultradistance running during the past 2 years and 11 physically inactive men who had been referred for arteriography but had no visible coronary artery disease. The internal diameter of the proximal segments of each major epicardial coronary artery was measured before and after nitroglycerin administration using a computer-based quantitative arteriographic analysis system. Measurements also included maximal oxygen uptake, plasma lipoprotein concentrations, body composition, and cardiac mass by echocardiography. Before nitroglycerin, the sum of the cross-sectional areas for the proximal right, left anterior descending, and circumflex arteries was not different for the runners and the inactive men: 22.7 +/- 4.79 versus 21.0 +/- 7.97 mm2 (p = 0.57), respectively. However, the increase in the sum of the cross-sectional area for the proximal right, left anterior descending, and circumflex arteries in response to nitroglycerin was greater for the runners (13.20 +/- 4.76 versus 6.00 +/- 3.02 mm2; p = 0.002). Left ventricular mass index (152 +/- 21 versus 116 +/- 41 g/m2; p < 0.05) but not left ventricular mass (284 +/- 40 versus 246 +/- 91 g; p = 0.22) was significantly greater for the runners. Among the runners, dilating capacity was positively correlated with aerobic capacity and negatively related to adiposity, resting heart rate, and plasma lipoprotein concentrations. CONCLUSIONS Highly trained, middle-aged endurance runners demonstrated a significantly greater dilating capacity of their epicardial coronary arteries in response to nitroglycerin compared with inactive men. The causes of this greater dilating capacity and its clinical significance need to be determined.
منابع مشابه
The effect of cardiac rehabilitation exercises on functional capacity and Ejection fraction in patients after coronary artery bypass graft surgery
Aims: The use of rehabilitation programs is effective in heart patients. Therefore, the aim of the present study was to determination the effect of cardiac rehabilitation exercises on functional capacity and ejection fraction in patients after coronary artery bypass graft surgery. Materials & Methods: For this purpose, 16 cardiac patients of Fatemeh Zahra Sari heart center who underwent CABG s...
متن کاملEffects of Eight Weeks of Cardiac Rehabilitation Training on Serum Levels of Sirtuin1 and Functional Capacity of Post- Coronary Artery Bypass Grafting Patients
ABSTRACT Background and Objectives: Cardiac rehabilitation improves functional capacity of post-coronary artery bypass grafting (CABG) patients. Therefore, the aim of this study was to evaluate effects of eight weeks of cardiac rehabilitation on serum levels of sirutin1 (SIRT1) and functional capacity of post-CABG patients. Methods: Forty-five non-active men (mean ag...
متن کاملThe Effect of Mindfulness-Based Stress Reduction on Anxiety and Stress in Patients with Coronary Heart Disease after Coronary Artery Bypass Graft Surgery: A Single-Subject Study
Background and objectives: Coronary artery disease (CAD) is associated with negative emotions of anger and stress, which are one of the nonclinical risk factors of the disease. Therefore, evaluation of the effective therapeutic models alleviating the patients’ negative emotions is of paramount importance. This study aimed to examine the effect of mindfulness-based stress reduction (MBSR) on ang...
متن کاملRunning: the risk of coronary events : Prevalence and prognostic relevance of coronary atherosclerosis in marathon runners.
AIMS To quantify the prevalence of coronary artery calcification (CAC) in relation to cardiovascular risk factors in marathon runners, and to study its role for myocardial damage and coronary events. METHODS AND RESULTS In 108 apparently healthy male marathon runners aged >or=50 years, with >or=5 marathon competitions during the previous three years, the running history, Framingham risk score...
متن کاملIncidence of Atrial Fibrillation after Coronary Artery Bypass Graft Surgery and Its Risk Factors in Shiraz, Iran during 2017-18
Background and Objectives: Atrial fibrillation is one of the most common disorientations after coronary artery bypass graft surgery and can affect the chance of survival in the first year after surgery. The present study aimed to determine the incidence of atrial fibrillation after coronary artery bypass graft surgery and its risk factors. Methods: This cross-sectional study was performed on...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Circulation
دوره 87 4 شماره
صفحات -
تاریخ انتشار 1993